Benfotiamine
and Improvement in Nerve Conduction Velocity
A
Benfotiamine-vitamin B Combination in Treatment of
Diabetic Polyneuropathy
Stracke
H, Lindemann A, Federlin K.
Third
Medical Department,
University of Giessen, Germany.
Exp Clin Endocrinol Diabetes. 1996;104(4):311-6.
Abstract
In
a double-blind, randomized, controlled study, the
effectiveness of treatment with a combination of
Benfotiamine (a lipid-soluble derivative of vitamin B1
with high bioavailability) plus vitamin B6,B12 on
objective parameters of neuropathy was studied over a
period of 12 weeks on 24 diabetic patients with
diabetic polyneuropathy. The results showed a
significant improvement (p = 0.006) of nerve
conduction velocity in the peroneal nerve and a
statistical trend toward improvement of the vibration
perception threshold. Long-term observation of 9
patients with verum over a period of 9 months support
the results. Therapy-specific adverse effects were not
seen. The results of this double-blind investigation,
of the long-term observation and of the reports in the
literature support the contention that the neurotropic
benfotiamine-vitamin B combination represents a
starting point in the treatment of diabetic
polyneuropathy.
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