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Comparison
of Benfotiamine to Thiamine
Pharmacokinetics
of Thiamine Derivatives Especially of Benfotiamine
Loew
D.
Wuppertal,
Germany.
Int J Clin Pharmacol Ther. 1996 Feb;34(2):47-50.
Abstract
Pharmacokinetic
data of orally administered lipid-soluble thiamine
analogues like benfotiamine are reviewed and assessed.
It is quite clear that benfotiamine is absorbed much
better than water-soluble thiamine salts: maximum
plasma levels of thiamine are about 5 times higher
after benfotiamine, the bioavailability is at maximum
about 3.6 times as high as that of thiamine
hydrochloride and better than other lipophilic
thiamine derivates. The physiological activity (alphaETK)
increased only after benfotiamine was given. Due to
its excellent pharmacokinetic profile benfotiamine
should be preferred in treatment of relevant
indications.
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