Nerve Regeneration with Methylcobalamine
Ultra-high
dose methylcobalamine promotes nerve regeneration in
experimental acrylamide neuropathy. Watanabe T Kaji R
Oka N Bara W Kimura J, J Neurol Sci (1994 Apr)
122(2):140-3
Despite intensive searches for therapeutic agents, few
substances have been convincingly shown to enhance
nerve regeneration in patients with peripheral
neuropathies. Recent biochemical evidence suggests
that an ultra-high dose of methylcobalamin
(methyl-B12) may up-regulate gene transcription and
thereby protein synthesis. We examined the effects of
ultra-high dose of methyl-B12 on the rate of nerve
regeneration in rats with acrylamide neuropathy, using
the amplitudes of compound muscle action potentials (CMAPs)
after tibial nerve stimulation as an index of the
number of regenerating motor fibers. After
intoxication with acrylamide, all the rats showed
equally decreased CMAP amplitudes. The animals were
then divided into 3 groups; rats treated with
ultra-high (500 micrograms/kg body weight,
intraperitoneally) and low (50 micrograms/kg) doses of
methyl- B12, and saline-treated control rats. Those
treated with ultra-high dose showed significantly
faster CMAP recovery than saline-treated control rats,
whereas the low-dose group showed no difference from
the control. Morphometric analysis revealed a similar
difference in fiber density between these groups.
Ultra-high doses of methyl-B12 may be of clinical use
for patients with peripheral neuropathies.
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