Methylcobalamine and Diabetic Neuropathy
Clinical
usefulness of intrathecal injection of methylcobalamin
in patients with diabetic neuropathy Ide H Fujiya S
Asanuma Y Tsuji M Sakai H Agishi Y, Clin Ther (1987)
9(2):183-92
Seven men and four women with symptomatic diabetic
neuropathy were treated with methylcobalamine (2,500
micrograms in 10 ml of saline) injected intrathecally.
Treatment was begun when patients had good metabolic
control, as determined by measurements of plasma
glucose and hemoglobin, and was repeated several times
with a one-month interval between injections. Three
patients were re-treated one year after the last
intrathecal injection. Symptoms in the legs, such as
paresthesia, burning pains, and heaviness,
dramatically improved. The effect appeared within a
few hours to one week and lasted from several months
to four years. The mean peroneal motor-nerve
conduction velocity did not change significantly. The
mean (+/- SD) concentration of methylcobalamin in
spinal fluid was 114 +/- 32 pg/ml before intrathecal
injection (n = 5) and 4,752 +/- 2,504 pg/ml one month
after intrathecal methylcobalamin treatment (n = 11).
Methylcobalamine caused no side effects with respect
to subjective symptoms or characteristics of spinal
fluid. These findings suggest that a high
concentration of methylcobalamin in spinal fluid is
highly effective and safe for treating the symptoms of
diabetic neuropathy.
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