Regeneration of Motor Nerve Terminals with Methyl B12
Methylcobalamine
(methyl-B12) Promotes Regeneration of Motor Nerve
Terminals Degenerating in anterior gracile muscle of
gracile axonal dystrophy (GAD) mutant mouse
Yamazaki
K Oda K Endo C Kikuchi T Wakabayashi T, Neurosci Lett
(1994 Mar 28) 170(1):195-7
We
examined the effects of methylcobalamin (methyl-B12,
mecobalamin) on degeneration of motor nerve terminals
in the anterior gracile muscle of gracile axonal
dystrophy (GAD) mutant mice. GAD mice received orally
methyl-B12 (1 mg/kg body wt/day) from the 40th day
after birth for 25 days. In the distal endplate zone
of the muscle, although most terminals were
degenerated in both the untreated and
methyl-B12-treated GAD mice, sprouts were more
frequently observed in the latter. In the proximal
endplate zone, where few degenerated terminals were
seen in both groups of the mice, the perimeter of the
terminals was increased and the area of the terminals
was decreased significantly in the methyl-B12-treated
GAD mice. These findings indicate that methyl-B12
promotes regeneration of degenerating nerve terminals
in GAD mice.
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