The term metabolic neuropathy refers to nerve disorders associated
with systemic diseases of metabolic origin.
Metabolic: relating to or deriving from the metabolism of a living organism.
Coming from the Greek: μεταβολή metabolē,
"change". It is the set of life-sustaining chemical transformations within the cells of living organisms.
The term "metabolic" is often used to refer specifically to the breakdown of food and its transformation into energy.
These metabolic diseases include diabetes mellitus, hypoglycemia,
uremia, hypothyroidism, hepatic failure,
polycythemia, amyloidosis, acromegaly, porphyria,
disorders of lipid/glycolipid metabolism,
nutritional/vitamin deficiencies, and mitochondrial
disorders, among others.
The common factor of
these diseases is damage to the nerves
by alteration of the structure or function of the myelin
sheath and axons due to metabolic pathway
Dystregulation is defined as: impairment of a physiological regulatory mechanism (as that governing metabolism, immune response, or organ function)
Diabetes is the most common cause of metabolic
neuropathy, followed by uremia.
Some of these disorders also
affect muscles due to the fact that the conditions
damage motor nerves which send incorrect signals to
about nerve damage read Neuropathy