Calm Biotect™
Calm Biotect™ is designed to support healthy stress management, promote restful sleep, and encourage a calm, balanced mind.
It combines brain-supporting amino acids with a blend of organic botanical extracts—including valerian, chamomile, passionflower, and ashwagandha—to work together in supporting emotional well-being and cognitive health.
Research suggests these ingredients may influence neurotransmitter activity in the brain, helping to promote relaxation, calmness, and healthy sleep patterns.
Key Benefits
* Supports relaxation and mental calmness
* Promotes restful, restorative sleep
* Contains calming organic botanicals: ashwagandha, valerian, passionflower, and chamomile
* Includes L-tryptophan, an amino acid used by the body to produce serotonin and melatonin
* Vegan formula free from gluten, dairy, and GMOs
* Manufactured in a GMP-certified, FDA-regulated facility
Bottle Size: 120 capsules (60-day supply)
Caution: If you are pregnant, nursing, or taking medication, consult your healthcare provider before use.
Key Ingredients
L-Tryptophan
L-tryptophan is an essential amino acid that the body converts into serotonin and melatonin in the brain. These hormones play important roles in regulating mood and supporting healthy sleep cycles.
L-Theanine
L-theanine is a naturally occurring amino acid found primarily in tea, especially green tea, where it makes up about 1–2% of the leaf’s dry weight. Research suggests that L-theanine may help reduce stress and promote relaxation.
GABA
GABA (gamma-aminobutyric acid) is a neurotransmitter that plays a key role in regulating sleep, circadian rhythms, and the body’s stress response. It occurs naturally in foods such as soybeans, fermented products, tea, and adzuki beans. Supplemental GABA has been shown to support relaxation and stress reduction.
Phosphatidylserine
Phosphatidylserine is a major phospholipid found in brain cell membranes. It plays an important role in cellular communication and helps regulate neurotransmitter release.
Ashwagandha
Ashwagandha (Withania somnifera) is an herb traditionally used in Ayurvedic medicine.
Known for its antioxidant and anti-inflammatory properties, clinical studies suggest it may help reduce stress and support overall well-being.
Calm Biotect™ uses organic ashwagandha.
Organic Botanical Blend
Passionflower
Passionflower is a purple flowering vine native to the Southeastern United States. It has traditionally been used to support healthy stress levels and improve sleep quality.
Valerian
Several randomized controlled studies on valerian root have reported improvements in sleep duration, sleep quality, and reductions in stress.
Chamomile
Chamomile tea has long been associated with calming effects. It contains beneficial phytochemicals, including the flavonoid apigenin.
Recent studies on chamomile extract supplementation support its potential role in promoting relaxation and better sleep.
Animal research suggests that L-theanine and plant compounds from passionflower, valerian, and chamomile may influence levels of the neurotransmitter GABA, which is associated with relaxation and sleep support.
Learn more and Order at Calm Biotect™
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Scientific Studies
What research supports this product?
The development of Calm Biotect™ was informed by scientific research examining the effects of amino acids and botanical compounds on stress, sleep, mood regulation, and neurotransmitter activity.
Below are the studies that informed the development of this product:
1. Jenkins TA, Nguyen JC, Polglaze KE, Bertrand PP. Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis. Nutrients 2016, 8.
2. White DJ, de Klerk S, Woods W, et al. Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial. Nutrients 2016, 8.
3. Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biol Psychol 2007, 74:39-45.
4. Hepsomali P, Groeger JA, Nishihira J, Scholey A. Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review. Front Neurosci 2020, 14:923.
5. Kim HY, Huang BX, Spector AA. Phosphatidylserine in the brain: metabolism and function. Prog Lipid Res 2014, 56:1-18.
6. Pratte MA, Nanavati KB, Young V, Morley CP. An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). J Altern Complement Med 2014, 20:901-908.
7. Akhondzadeh S, Naghavi HR, Vazirian M, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther 2001, 26:363-367.
8. Miyasaka LS, Atallah AN, Soares BG. Passiflora for anxiety disorder. Cochrane Database Syst Rev 2007:CD004518.
9. Movafegh A, Alizadeh R, Hajimohamadi F, et al. Preoperative oral Passiflora incarnata reduces anxiety in ambulatory surgery patients: a double-blind, placebo-controlled study. Anesth Analg 2008, 106:1728-1732.
10. Shinjyo N, Waddell G, Green J. Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis. J Evid Based Integr Med 2020, 25:2515690X20967323.
11. Adib-Hajbaghery M, Mousavi SN. The effects of chamomile extract on sleep quality among elderly people: A clinical trial. Complement Ther Med 2017, 35:109-114.
12. Amsterdam JD, Li Y, Soeller I, et al. A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. J Clin Psychopharmacol 2009, 29:378-382.
13. Keefe JR, Guo W, Li QS, et al. An exploratory study of salivary cortisol changes during chamomile extract therapy of moderate to severe generalized anxiety disorder. J Psychiatr Res 2018, 96:189-195.
14. Mao JJ, Xie SX, Keefe JR, et al. Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial. Phytomedicine 2016, 23:1735-1742.
15. Savage K, Firth J, Stough C, Sarris J. GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence. Phytother Res 2018, 32:3-18.
16. Lardner AL. Neurobiological effects of the green tea constituent theanine and its potential role in the treatment of psychiatric and neurodegenerative disorders. Nutr Neurosci 2014, 17:145-155.