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What are the Factors that can Cause Neuropathy or Nerve Damage - the Risk Factors

How do you get neuropathy?

Nerve lining breaking down - myelin sheathNeuropathic Pain and other symptoms of nerve damage can be caused by many things.  The damage is caused by the breakdown of the myelin sheath. (see photo)

Often it is diabetics that suffer from this type of nerve pain due to the high blood sugars of the disease damaging the nerves  and it is a major complication of the disease.

However, there are a lot causes for nerve damage and we have listed them below (alphabetically). 

It can sometimes be a combination of reasons.  It is an acquired disease.

  • Accidents and falls where nerves get damaged.- See Trauma
  • Agent Orange herbicide dumped on Vietnam between 1962 and 1971 to kill jungle foliage with the aim of exposing enemy targets.
    Toxin that has been reported to cause health problems including nerve damage. 
  • AIDS, see infectious disease
  • Alcoholism - Thiamine (B1) deficiency, in particular, is common among people who use alcohol because alcohol contributes to poor dietary habits. Thiamine deficiency can cause a painful neuropathy of the extremities. Some researchers believe that excessive alcohol consumption may, in itself, contribute directly to nerve damage, a condition referred to as alcoholic neuropathy.
  • Amyloidosis (metabolic disorder) - an disorder where a protein called amyloid is deposited in tissues and organs. Amyloidosis can affect peripheral sensory, motor or autonomic nerves and deposition of amyloid lead to degeneration and dysfunction in these nerves.  See Amyloidosis
  • Anemia - Vitamin Deficiencies. A diet that lacks iron, folic acid (folate), or vitamin B12 can prevent your body from making enough red blood cells. A deficiency of iron can effect nerve conduction. A lack of B12 damages the myelin sheath that surrounds and protect nerves. Without this protection, nerves cease to function properly and conditions such as peripheral neuropathy occur. Even B12 deficiency that is relatively mild may affect the nervous system and the proper functioning of the brain. The nerve damage caused by a lack of B12 may become permanently debilitating, if the underlying condition is not treated.
  • Antibiotics - certain antibiotics have been known to have a side effect of neuropathy.  The FDA even warned physicians about this regarding Fluoroquinolones.  Fluroquinolones are a class of antibiotics with a broad spectrum of antimicrobial activity.  Fluoroquinolones are - levofloxacin (Levaquin), ciprofloxacin (Cipro), moxifloxacin (Avelox), norfloxacin (Noroxin), ofloxacin (Floxin), and gemifloxacin (Factive).  The topical fluoroquinolones isn't believed to cause this problem. 
  • Autoimmune responses  - when the body attacks its own tissues. (such as occurs in Guillain-Barre syndrome)
  • Autoimmune disorders - Viral and bacterial infections can also cause indirect nerve damage by provoking conditions referred to as autoimmune disorders, in which specialized cells and antibodies of the immune system attack the body's own tissues. These attacks typically cause destruction of the nerve's myelin sheath or axon (the long fiber that extends out from the main nerve cell body).
  • Bacterial Infections - Lyme disease, diphtheria, and leprosy are bacterial diseases characterized by extensive peripheral nerve damage. Diphtheria and leprosy are now rare in the United States, but Lyme disease is on the rise. It can cause a wide range of neuropathic disorders, including a rapidly developing, painful polyneuropathy, often within a few weeks after initial infection by a tick bite. See autoimmune responses.
  • Bariatric Surgery - postoperative nerve damage also known as peripheral neuropathy (PN) Nutritional deficiencies can occur following this procedure due to patients experiencing more weight loss than expected and post operative complications. See Surgery 
  • B1, B6, Deficiency & B12 Deficiency - See Vitamin Deficiencies
  • B6 Toxicity - it is believed that too much, over 100 mg/day of B6 causes neuropathy.   You should note that when you overwhelm the system with only one B vitamin, it can cause a deficiency of other vitamin Bs.  The body needs to have all the B vitamins working together and thus will rob the body of its stores of the B vitamins you get in your food in order to do this.  Thus, using up the other B vitamins to balance with the B6.  B1 & B12 are important for nerve function and lack of these can cause neuropathy.
  • Bell's Palsy - Bell's palsy results from upper respiratory infections, viral infections such as those caused by infectious mononucleosis, herpes, mumps, HIV viruses, and bacterial infections such as Lyme Disease. Facial weakness from Bell's palsy is due to the facial nerve which is a nerve that controls the muscles on the side of the face and it a form of peripheral neuropathy.
  • Bruxism - teeth grinding
  • Cancer - such as multiple myeloma, which damages nerves by directly invading or putting pressure on them or by triggering an autoimmune reaction.  A tumor can press on a nerve or entrap a nerve and cause damage. See Compression neuropathy
  • Cancer Treatments - See Chemotherapy treatments and Radiation Therapy
  • Carpal tunnel syndrome - Carpus comes from the Greek word for wrist. The wrist is surrounded by a band of fibrous tissue that normally functions as a support for the joint. The tight space between this fibrous band and the wrist bone is called the carpal tunnel. The median nerve passes through the carpal tunnel to receive sensations from the thumb, index, and middle fingers of the hand. Any condition that causes swelling or a change in position of the tissue within the carpal tunnel can squeeze and irritate the median nerve. Irritation of the median nerve in this manner causes tingling and numbness of the thumb, index, and the middle fingers, a condition known as "carpal tunnel syndrome." Thus, it can cause nerve damage.
  • Celiac Disease - is an autoimmune problem and can cause neuropathy
  • Charcot-Marie-Tooth disease - it is believed to be an Inherited neuropathy
  • Post Chemotherapy Treatment  (See Chemo-Induced Side effects for other side effects)) See Chemotherapy Induced Peripheral Neuropathy
  • Cholesterol lowering drugs such as Lipitor.  These block cholesterol which the nerves are made of. 
  • Chronic kidney failure - Chronic kidney or renal failure (uremia) occurs when the kidneys gradually fail to function properly. When the kidneys are impaired, fluids and waste products accumulate in the body. In some cases, kidney failure can cause peripheral neuropathy. Many conditions can cause kidney failure; the most common are diabetes and high blood pressure.
  • Compression of nerves (called compression neuropathy) - pressure on an area. It is an inability to transmit nerve impulses because compression has damaged nerve fibers either directly, or indirectly by restricting their supply of oxygen. Compression can come from herniated discs in the spine, osteoarthritis can cause bone spurs that can compress a nerve, severe muscle injuries can compress nerves, and even prolonged use of tight clothing such as shoes or skinny jeans.. It all depends on the nerve compressed.   See the neuropathy of Skinny jeans
  • Connective tissue disease - (e.g., rheumatoid arthritis, lupus, sarcoidosis) Connective tissue disorders and chronic inflammation can cause direct and indirect nerve damage. When the multiple layers of protective tissue surrounding nerves become inflamed, the inflammation can spread directly into nerve fibers. Chronic inflammation also leads to the progressive destruction of connective tissue, making nerve fibers more vulnerable to compression injuries and infections. Joints can become inflamed and swollen and entrap nerves, causing pain.
  • Crohn's Disease - inflammatory bowel disease see inflammation
  • Cryoglobulinemia (which literally means "cold antibody in the blood")
  • Cytomegalovirus (CMV) - see viral infections
  • Denture Cream use
  • Dental Surgery
  • Diabetes mellitus - due to high blood sugar damaging the nerves -  the higher than normal sugar levels create nerve damage. Chronic neuropathy can start when the nerves are deprived of oxygen or anoxia. See Diabetic Nerve Pain
  • Diabetic Drug - Metformin - Metformin has been known to deplete the body of B12.  A B12 Deficiency is a cause of nerve damage. See articles below under Metformin
  • Diet - lack of B vitamins necessary to nerve function and preseravatives, etc. in processed foods. 
  • Diphtheria - See Bacterial Diseases
  • Drugs - Certain anticancer drugs, anticonvulsants, antiviral agents, phenytoin, some antibiotics (such as chloramphenicol, nitrofuranton, levofloxacin and sulfonamides), some sedatives (such as barbital and hexobarbital),  have side effects that can include peripheral nerve damage, thus limiting their long-term use. Metformin is a drug associated with B12 deficiency and thus nerve damage. Metformin & Vitamin B12 Deficiency To check on any medications and if they cause nerve damage, go to www.drugs.com or www.rxlist.com Note: neuropathy can be defined as nerve pain, parenthesia, tingling and numbness..etc.  See Medications for more info.
  • Epstein-Barr virus - See Infections
  • Erectile-Dysfunction Drug - there is some evidence it might create optic neuropathy. See article
  • Excitoxins - additives to certain processed food products that stimulate hunger and disrupt normal appetite control. See below - Foods that are Toxic
  • Foods that are toxic Some foods and food additives have a direct toxic effect on the gastrointestinal tract. Food allergies and intolerance can create nerve pain - neuropathy. MSG is known to cause nerve damage.
  • Fungus - fungal infections or just exposure to fungus/mold can cause nerve damage - more info see Know the Cause webiste for sources of fungus, including the food you eat. 
  • Gluten intolerance - See Autoimmune Responses
  • Growth Hormone, Overproduction - See Metabolic Disorder
  • Guillain-Barré Syndrome / Acute Inflammatory Demyelinating Polyneuropathy (AIDP) 
  • Heavy Metal Toxicity - especially lead, arsenic & mercury
  • Hepatitis B - see Infections
  • Hepatitis C - see Infections
  • Hereditary - there is a belief that neuropathy can be inherited.  A closer look at the other causes on this page, might result in an actual cause.  Sometimes hereditary is too easy to assign. 
  • Herniated disc - most compressed nerves will cause inflammation but will get better. This is more likely to cause problems when the nerve is squashed between the disc and an adjacent bone.
  • Herpes Zoster (Shingles), see viral infections
  • HIV/AIDS - The human immunodeficiency virus (HIV), which causes AIDS, also causes extensive damage to the central and peripheral nervous systems. The virus can cause several different forms of neuropathy, each strongly associated with a specific stage of active immunodeficiency disease. A rapidly progressive, painful polyneuropathy affecting the feet and hands is often the first clinically apparent sign of HIV infection.- see viral infections
  • Hormonal imbalances - can disturb normal metabolic processes and cause neuropathies. For example, an underproduction of thyroid hormones slows metabolism, leading to fluid retention and swollen tissues that can exert pressure on peripheral nerves. Overproduction of growth hormone can lead to acromegaly, a condition characterized by the abnormal enlargement of many parts of the skeleton, including the joints. Nerves running through these affected joints often become entrapped.
  • Hypothyroidism - See Metabolic disorders
  • Idiopathic when doctors cannot seem to find a specific cause, they call it idiopathic neuropathy.
  • Immune System - See Inflammation
  • Inflammation - Chronic inflammation also leads to the progressive destruction of connective tissue, making nerve fibers more vulnerable to compression injuries and infections. Joints can become inflamed and swollen and entrap nerves, causing pain.  Some neuropathies are caused by inflammation resulting from immune system activities rather than from direct damage by infectious organisms. Inflammatory neuropathies can develop quickly or slowly, and chronic forms can exhibit a pattern of alternating remission and relapse. Acute inflammatory demyelinating neuropathy, better known as Guillain-Barré syndrome, can damage motor, sensory, and autonomic nerve fibers. Most people recover from this syndrome although severe cases can be life threatening. Chronic inflammatory demyelinating polyneuropathy (CIDP), generally less dangerous, usually damages sensory and motor nerves, leaving autonomic nerves intact. Multifocal motor neuropathy is a form of inflammatory neuropathy that affects motor nerves exclusively; it may be chronic or acute.
  • Infections - involving a toxin produced by bacteria or viruses.
  • Infectious disease (e.g., Lyme disease, HIV/AIDS, hepatitis B, leprosy)  Infections and autoimmune disorders can cause peripheral neuropathy. Viruses and bacteria that can attack nerve tissues include herpes varicella-zoster (shingles), Epstein-Barr virus, cytomegalovirus, and herpes simplex-members of the large family of human herpes viruses. These viruses severely damage sensory nerves, causing attacks of sharp, lightning-like pain. Postherpetic neuralgia often occurs after an attack of shingles and can be particularly painful.
  • Inherited forms of peripheral neuropathy are believed to be caused by inborn mistakes in the genetic code or by new genetic mutations. Some genetic errors lead to mild neuropathies with symptoms that begin in early adulthood and result in little, if any, significant impairment. More severe hereditary neuropathies often appear in infancy or childhood.  The most common inherited neuropathies are a group of disorders collectively referred to as Charcot-Marie-Tooth disease. These neuropathies result from flaws in genes responsible for manufacturing neurons or the myelin sheath. Hallmarks of typical Charcot-Marie-Tooth disease include extreme weakening and wasting of muscles in the lower legs and feet, gait abnormalities, loss of tendon reflexes, and numbness in the lower limbs  .The sad fact is that after a while this misfiring of the nerves can get so bad that people are unable to walk or pick things up and can get to a point where they would rather have a limb amputated then continue with this nerve pain.  
  • Kidney failure - can lead to abnormally high amounts of toxic substances in the blood that can severely damage nerve tissue. A majority of patients who require dialysis because of kidney failure develop polyneuropathy. 
  • Leprosy Infection - In all patients with leprosy, the nerve tissue is involved. The dermal nerves are infected in all skin lesions.  
  • Liver disease & liver  failure - liver disease may be associated with sensory-motor demyelinating polyneuropathy  Some liver diseases also lead to neuropathies as a result of chemical imbalances.
  • Lumbar Back Surgery
  • Lupus - Systemic Lupus Erythematosus,  See Connective Tissue Diseases
  • Lyme Disease - see Bacterial Infection
  • Medications can have a side effect of neuropathy - Lyrica, Cymbalta, Duloxetine hydrochloride, Pregabalin, and more. See Neuropathy as a Side Effect     (see: Medications  Is your medication not on the list?  You can also check www.rxlist.com or  www.drugs.com  to check 
  • Mercury poisoning
  • Metabolic Disorders caused by a disruption of the chemical processes in the body. In some cases, nerve damage is caused by the inability to properly use energy in the body. In other cases, dangerous substances (toxins) build up in the body and damage nerves. Some metabolic disorders are pass down through families (inherited), while others are develop due to various diseases.
  • Metformin Use (see Vitamin B12 Deficiency and Metformin Usage Trigger Peripheral Neuropathy) or this article Metformin May Cause Low B12, Nerve damage
  • Monoclonal Gammopathy
  • MSG - see article MSG 
  • Multiple Sclerosis - During periods of multiple sclerosis activity, white blood cells are drawn to regions of the white matter. These initiate and take part in what is known as the inflammatory response. The resulting inflammation is similar to what happens in your skin when you get a pimple. During the inflammation, the myelin gets stripped from the axons in a process known as demyelination.  Note: sometimes heavy metal poisoning can be misdiagnosed as MS as the symptoms appear to be similar.
  • Multifocal Motor Neuropathy (MNN) see article on Motor Neuropathy
  • Nutritional Deficiencies - See Vitamin Deficiencies
  • Parvo - Parvovirus, often truncated to "parvo", is both the common name in English casually applied to all the viruses in the Parvoviridae taxonomic family, see Viral infections
  • POEMS -  syndrome is a rare multisystem disorder caused by the improper growth of bone marrow cells, resulting in an abnormal accumulation of proteins (immunoglobulin) in tissues and organs
  • Polyarteritis nodosa (PAN) is a vasculitis of medium & small-sized arteries, arteries, which become swollen and damaged from attack by rogue immune cells.   See Autoimmune responses. 
  • Porphyia - Porphyrias are a group of rare disorders passed down through families, in which an important part of hemoglobin, called heme, is not made properly.  Lack of oxygen reaching the nerves due to lack of hemoglobin, which carries oxygen is a likely cause of the nerve damage. Medical science doesn't know the reason. 
  • Pressure on a nerve - See Compression neuropathy
  • Radiation Treatment - effects may be delayed for many years, the radiation can injury the nerves
  • Radiculopathy - is a condition due to a compressed nerve in the spine that can cause pain. See compression neuropathy
  • Rat Lung Worm - Angiostrongylus cantonensis, or rat lungworm, is a parasitic nematode (roundworm) that spends it natural life cycle in the bodies of rats and mollusks. This problem is prevalent in Hawaii. One of the side effects is nerve damage. See Rat lungworm
  • Reflux & Heartburn Medications - in a study done and published in the Jouranl of the American Medical Association (JAMA) prolonged use of medications can cause B12 deficiency. B12 deficiency is a cause of neuropathy. See article
  • Renal Failure, See Kidney Failure
  • Repetitive Stress - frequently leads to entrapment neuropathies, a special category of compression injury. Cumulative damage can result from repetitive, forceful, awkward activities that require flexing of any group of joints for prolonged periods. The resulting irritation may cause ligaments, tendons, and muscles to become inflamed and swollen, constricting the narrow passageways through which some nerves pass
  • Rheumatoid Arthritis - See Connective Tissue Disease
  • Riding Accidents - Horse falling on rider and damaging nerves
  • Sarcoidosis - is a disease in which inflammation occurs in the lymph nodes, lungs, liver, eyes, skin, or other tissues .See Connective tissue diseases
  • Shingles, See Infections Disease
  • Sjögren's Syndrome - See Inflammatory disease,
  • Statin Drugs - designed to block cholesterol, the cells need cholesterol to build the myelin sheath. Also, elevated body burden of mercury- high levels of cholesterol are the body’s protective mechanism against some environmental toxins, particularly mercury. Aggressive lowering of cholesterol may result in increased toxicity from these sources. It is proposed that this may be the mechanism of the nerve damage that occurs as a side effect of some statin drugs.   Article Neuropathy & Statins
  • Surgery  Often, during the course of surgery it is often possible that nerves may become damaged. 
  • Swollen blood vessels - See Compression neuropathy
  • Systemic Diseases - disorders that affect the entire body —often cause peripheral neuropathy. These disorders may include: Metabolic and endocrine disorders. Nerve tissues are highly vulnerable to damage from diseases that impair the body's ability to transform nutrients into energy, process waste products, or manufacture the substances that make up living tissue. Diabetes mellitus, characterized by chronically high blood glucose levels, is a leading cause of peripheral neuropathy in the United States. About 60 percent to 70 percent of people with diabetes have mild to severe forms of nervous system damage.
  • Thyroid, underactive
  • Toxic substances  - It can cause peripheral nerve damage. People who are exposed to heavy metals (arsenic, lead, mercury, thallium), industrial drugs, or environmental toxins frequently develop neuropathy. See Neurotoxicity
  • Trapped, pinched or compressed nerves - entrapment neuropathy. See Compression Neuropathy
  • Trauma, including surgery. Physical Injuries - is the most common cause of injury to a nerve. Injury or sudden trauma, such as from automobile accidents, falls, and sports-related activities, can cause nerves to be partially or completely severed, crushed, compressed, or stretched, sometimes so forcefully that they are partially or completely detached from the spinal cord. Broken or dislocated bones can exert damaging pressure on neighboring nerves, and slipped disks between vertebrae can compress nerve fibers where they emerge from the spinal cord.
  • Tumors - causing pressure on a nerve - Cancers and benign tumors can infiltrate or exert damaging pressure on nerve fibers. Tumors also can arise directly from nerve tissue cells.
  • Vaccinations - there are always side effects from vaccinations, nerve damage being one of them.  Here is an article about this Vaccination related nerve damage. 
  • Vascular Damage and blood diseases - can decrease oxygen supply to the peripheral nerves and quickly lead to serious damage to or death of nerve tissues, much as a sudden lack of oxygen to the brain can cause a stroke. Diabetes frequently leads to blood vessel constriction. Various forms of vasculitis (blood vessel inflammation) frequently cause vessel walls to harden, thicken, and develop scar tissue, decreasing their diameter and impeding blood flow. This category of nerve damage, in which isolated nerves in different areas are damaged, is called mononeuropathy multiplex or multifocal mononeuropathy.
  • Vasculitis - inflammation of the blood vessels
  • Viral Infections - See Infections above.
    Viral and bacterial infections can also cause indirect nerve damage by provoking conditions referred to as autoimmune disorders, in which specialized cells and antibodies of the immune system attack the body's own tissues. These attacks typically cause destruction of the nerve's myelin sheath or axon (the long fiber that extends out from the main nerve cell body).
  • Vitamin deficiencies (e.g., pernicious anemia, etc.) can cause widespread damage to nerve tissue. Vitamins E, B1, B6, B12, and niacin are essential to healthy nerve function. See also alcoholic neuropathy. A lack of B12 damages the myelin sheath that surrounds and protect nerves. Without this protection, nerves cease to function properly and conditions such as peripheral neuropathy occur. Even B12 deficiency that is relatively mild may affect the nervous system and the proper functioning of the brain. The nerve damage caused by a lack of B12 may become permanently debilitating, if the underlying condition is not treated.  Vitamin D deficiency is also linked to neuropathy and often linked to diabetic neuropathy. Vitamin D is necessary along with the B vitamins needed for nerve health.  B6 taken in excessive amounts has been seen as contributing as well as folate deficiencies.
  • Zinc induced copper deficiency (denture adhesive creams use) These adhesive creams have a large amount of zinc in them which can induce a copper deficiency and then nerve damage. See vitamin deficiencies.
  • Zicam  See http://www.snopes.com/medical/drugs/zicam.asp ) Note:
    this type is no longer sold.  It was withdrawn from the market in 2009. It still might have caused a problem to those using it before it was withdrawn. 

For information about this nerve damage, what it is, why the symptoms, and what can be done about it.  See Neuropathy
 

Quote About Chronic Neuropathy & its cause:

ScienceDaily (June 29, 2009) "Multiple sclerosis, diabetic neuropathy, and other conditions caused by a loss of myelin insulation around nerves can be debilitating and even deadly, but adequate treatments do not yet exist."  

There is treatment for nerve health by building healthy nerves - see WSN Nerve Support Formula

 

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